The C-terminal modification reduces the total solubility of peptides by reducing the total charges of peptides. With C-terminal modification, the peptide is closer to the natural protein, the stability of the peptide is also improved. Therefore, these modifications can increase the biological activity of the peptide and the resistance of the peptide to enzymatic degradation. Our peptide synthesis team can prepare a variety of C-terminal modifications, including thiol (Cys side chain), Abz (Lys side chain), biotin (Lys or Cys side chain), other labels or dyes, etc. c-terminal peptide modification https://www.pepdd.com/services/c-terminal-modification.html