Nonetheless given that pain that is considered moderate to severe is in question people tend to opt for pain relief medication that can be purchased with a prescription and while Tapentadol an Tramadol are two rather popular medications in this group They are both synthetic opioids that produce their analgesic effects by binding to opioid receptors located in the central nervous system but they differ in regard to their pharmacology side effect prole, and indicated uses It is therefore important to compare Tapentadol with Tramadol in order to know which pain relief solution one needs.What is Tapentadol?Tapentadol 100mg tablet is another relatively recent analgesic medical agent differentiating itself through two key mechanisms An opioid analgesic of the central type and its mechanism involves interaction with both opioid receptors as well as blocking reuptake of norepinephrine This dual action mechanisms enable Tapentadol to be used to manage conditions such as moderate to severe pain as due to injury, surgery or chronic conditions including osteoarthritis and diabetic neuropathy There is an immediate release and extended-release formulation of this drug which means it can be given in different ways.What is Tramadol?There is also Tramadol which is a relatively older drug from the group of pain relievers classified as opioid like analgesic though its working is slightly different It works well on the mu opioid receptors in the brain to ease pain but acting also as an SSRI or SNRI since it slows the reabsorption of serotonin and norepinephrine neurotransmitters which play an instrumental role in pain modulation This action makes Tramadol resemble some antidepressants and aims it squarely as a mixed opiate-receptor agonist or analgesic Tramadol is given for mild to moderate pain but it is also useful for chronic pain–fibromyalgia low back pain and so on.How Tapentadol Differ from Tramadol