What Is Peptide AOD 9604?

What is AOD-9604?

Human growth hormone, naturally present in our bodies, has been shown to be effective in reducing fat mass, leading to weight loss. AOD-9604 is a human growth hormone (hGH) analog, meaning it is synthetic and structurally and functionally similar to hGH. Several studies have evaluated the effect of AOD-9604 on the body in the context of weight loss.

How does AOD-9604 reduce fat mass?

AOD 9604 peptide for weight loss on acts adipose tissue, also known as body fat. It activates a biological process called lipolysis, which refers to the breakdown of fats and other lipids. AOD-9604 may also induce fat loss. One animal study, for example, showed that AOD-9604 could promote weight loss in genetically obese rats and mice. In a 23-week randomized clinical trial in humans, participants taking 1 mg of AOD-9604 per day experienced an average weight loss of 2.8 kg, compared to 0.8 kg in those taking a placebo.

Despite these results, development of AOD-9604 was discontinued in 2007 because the drug failed to produce significant weight reduction in 536 subjects over 24 weeks.

How AOD-9604 Works in the Body

1. Activates Fat-Burning Receptors

AOD-9604 works by stimulating beta-3 adrenergic receptors found in adipose (fat) tissue, which are key regulators of lipolysis, the process of breaking down stored fat. Once activated, these receptors initiate the conversion of triglycerides into free fatty acids and glycerol, which are then used for energy production (Heffernan et al., 2000).

2. Increases metabolism without muscle loss

AOD-9604 improves metabolic efficiency by:

Upregulating fat-metabolizing enzymes

Increasing resting calorie expenditure

Sparing lean muscle mass, a key factor in long-term weight management

This contrasts with traditional weight loss approaches, which often result in a loss of both fat and muscle, leading to a decrease in basal metabolic rate.

3. Promotes insulin sensitivity

Emerging data suggest that AOD-9604 may also improve insulin sensitivity, potentially helping to:

Stabilize blood sugar levels

Reduce the risk of type 2 diabetes

Improve nutrient partitioning

This makes it particularly relevant for people with metabolic syndrome or insulin resistance (Ng et al., 2000).

The Science Behind AOD-9604 and Weight Loss

AOD-9604 was designed by isolating the lipolytic (fat-burning) region of the human growth hormone (HGH) molecule, specifically amino acids 176 to 191. This fragment retains HGH's fat-burning ability but lacks the growth-promoting effects that contribute to organ enlargement, joint pain, and insulin resistance.

Clinical Evidence

Human Trials: A randomized, placebo-controlled study in obese adults demonstrated that AOD-9604 significantly reduced abdominal and total body fat mass over several weeks of treatment, without serious side effects (Ng et al., 2000).

Animal Studies: Preclinical studies in mice and rats have shown that AOD-9604:

• stimulated lipolysis;
• inhibited lipogenesis (formation of new fat);
• prevented weight gain despite high-fat diets (Heffernan et al., 2000).

This dual action, which promotes the breakdown of fat and inhibits its formation, makes AOD-9604 a powerful tool in the fight against obesity.

Side Effects of AOD 9604 Peptides

Although AOD 9604 is considered a GRAS (Generally Recognized as Safe) treatment, some patients have experienced the following symptoms:

• Redness, swelling, and pain at the injection site
• Stomach upset
• Headache

Patients were more susceptible to side effects when combining the treatment with other injections or medications. Therefore, it is essential to inform your doctor of all your prescriptions before deciding to use AOD 9604 Peptides.

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