Global Syphilis Testing Market Set to Reach USD 2.21 Billion by 2031 Driven by Dual HIV/Syphilis Rapid Diagnostics

[Geneva, 19 August 2025] – According to Clearview Market Insights (CVMI), the global syphilis testing market is forecasted to grow from USD 1.37 billion in 2024 to USD 2.21 billion by 2031, expanding at a CAGR of 7.1%. Rising adoption of dual HIV/syphilis rapid tests and the expansion of decentralized diagnostic services are fueling this growth, particularly in maternal care and low-resource regions.

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“Syphilis remains a priority in global STI control strategies due to its resurgence and risk of congenital transmission,” said Dr. Helene Roche, Infectious Disease Markets Principal at CVMI. “Affordable, easy-to-use diagnostics are bridging critical gaps in underserved populations.”

Key players including Abbott, Bio-Rad, and SD Biosensor are shaping the industry with strong global footprints. SD Biosensor’s handheld readers are gaining significant adoption across African and Southeast Asian outreach clinics, while Abbott’s Determine combo tests and Bio-Rad’s automated TPHA/RPR analyzers are advancing high-volume screening programs in public health infrastructures.

Support from WHO, UNAIDS, and The Global Fund is accelerating adoption in high-burden countries, while Latin America explores self-testing pilots, and North America and Europe strengthen universal antenatal screening.

Recent developments include Thermo Fisher’s acquisition of a treponemal PCR innovator, highlighting the growing importance of molecular diagnostics in syphilis detection. Manufacturers are also emphasizing AI-enabled POCT systems, rugged analyzers, and resilient reagent supply chains to meet global demand.

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