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Regardless of the type, the effect of these medicines is the same. The drugs are so named because of their specific inhibitory effect on the enzyme PDE5, which is present in the tissues of the penis. PDE5 (phosphodiesterase type 5) inhibitor specifically inhibits the enzyme PDE5 responsible for preventing an erection from being achieved or maintained. Kamagra blocks the activity of the phosphodiesterase type 5 inhibitor in the breakdown of cyclic guanosine monophosphate (cGMP), which is responsible for controlling blood flow to the penis via the relaxation of smooth muscles that mediate the erection response in patients. Since there is no phosphodiesterase type 5 inhibitor that blocks the action of cGMP in the patients, the cGMP level sufficient to elicit the erectile response is maintained. Why Must Kamagra, Or Other PDE5 Inhibitors, Inhibit PDE5? The inhibitory action of these drugs is essential to ensure that an erection occurs. The enzyme PDE5 blocks the presence of cGMP (cyclic guanosine monophosphate), which is actually not good because cGMP is responsible for relaxing the smooth muscles of the penis, increasing blood volume in the spongy corpus cavernosum. The increased blood volume in the penile tissue drives the erection response, so the presence of cGMP must be maintained to get and maintain the erection. PDE5 inhibitors such as Kamagra Oral Jelly help maintain the presence of cGMP in the penile tissue for up to 4 hours by preventing the breakdown of cGMP by PDE5. Who Makes Kamagra Oral Jelly? The manufacturer of Kamagra Oral Jelly is India-based multinational company Ajanta Pharma. The company was founded in 1973 and is engaged in the production, marketing and distribution of pharmaceutical products in the form of tablets, capsules, dry powders, liquid formulations, jellies, and others. 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We offer online medicines in the Netherlands. When Does Erectile Dysfunction Occur? Erectile dysfunction becomes more common as men get older. It is also associated with certain medical conditions, such as heart disease and diabetes. In fact, men with diabetes are four times more likely to have erectile dysfunction than men without diabetes. They also tend to develop erectile dysfunction ten to fifteen years earlier and tend to have more severe cases. What Causes Erectile Dysfunction? Kamagra Oral Jelly 100mg least one in ten men sometimes has trouble getting or keeping an erection. There may be physical or psychological causes, or a combination of both. Whatever the cause, due to changes in the muscles and blood vessels, not enough blood stays in the penis to make it hard and keep it hard. Here are some possible causes: hormonal problems; Nerve damage. When a man is sexually aroused, his brain sends messages to his penis to initiate the erection process. 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