Sarcoidosis is a systemic disease of unknown etiology defined by the presence of noncaseating granulomatous inflammation that can cause organ damage and diminished quality of life. The lungs and the lymph nodes are most affected by the problem other parts of the body are impacted as well including the eyes, heart, and skin. Chest pain, shortness of breath, Fainting episodes, and a constant feeling of fatigue with palpitations and arrhythmia are some of the chief symptoms of sarcoidosis; approximately 1-5% of patients affected with sarcoidosis can die because of complications associated with the disease.

Corticosteroids are often the first line of treatment in sarcoidosis cases but apart from corticosteroids, Buy Hydroxychloroquine online is another drug that had yielded successful results in successfully managing Sarcoidosis cases.

Hydroxychloroquine sold under the brand name of Plaquenil is an antimalarial and 4-aminoquinoline medication used in the treatment of uncomplicated malaria conditions. In addition, it is DMARD ( Disease Modifying Anti-Rheumatic Drug) is used in the treatment of rheumatic conditions. Rheumatoid Arthritis, juvenile arthritis, post Lyme- induced arthritis, cases of lupus erythematosus and Sjogren's Syndrome are some of the chief conditions in which Hydroxychloroquine is used to provide therapeutic relief to the patient

Hydroxychloroquine increases the lysosomal pH in antigen-presenting cells and exerts its binding effects on the T-cells of the human body to bring out its therapeutic effects. Usually, corticosteroids are the first choice of treatment for sarcoidosis conditions followed by antimetabolites like methotrexate (MTX), azathioprine (AZA), and mycophenolate mofetil (MMF). antimalarial agents like Hydroxychloroquine have been proven extremely effective in sarcoidosis conditions as a result of their immunomodulatory properties. In particular, conditions of pulmonary sarcoidosis affecting the lungs, and cutaneous sarcoidosis affecting the lungs, skin, and eyes respond to the use of Hydroxychloroquine.

To achieve its therapeutic functions, Hydroxychloroquine prevents the acidification of lysosomal enzymes necessary for antigen presentation and toll-like receptor 2 activations. They in turn inhibit the conversion of 25-(OH)vitamin D to 1,25-(OH)vitamin and suppresses sarcoidosis-associated hypercalcemia and hypercalciuria; conditions of extra calcium in the blood and urine resulting in symptoms of stomach pain, renal stones, and other complicated situations for the patient.

Hydroxychloroquine and its derivatives like Chloroquine have large-volume tissue distribution, longer half-life, and similar rates of renal excretion, and using them in sarcoidosis conditions can reduce the symptomatic complaints of the patient to a considerable extent. Care needs to be taken during the use of Hydroxychloroquine to avoid their concomitant use with heart medications like Digoxin and Metoprolol as it may reduce the absorption rate of either medication and increase/decrease their plasma concentration in the blood.

In addition to conditions of skin sarcoidosis, symptoms o skin sarcoidosis, hypercalcemia, and myalgia are effectively addressed through the use of Hydroxychloroquine. Studies have even suggested the role of medication in lung sarcoidosis conditions though clinical studies are relatively limited in demonstrating their effectiveness in lung sarcoidosis conditions.  A randomized placebo-controlled study of 18 pulmonary sarcoidosis patients, initially treated for 6 months with CQ 750 mg/day, tapering every 2 months to 250 mg, reported a significant improvement in symptoms and lung function, but relapses were observed after the drug was discontinued. Unlike immunosuppressant drugs, Hydroxychloroquine use is not associated with an increased risk of infectious complications.