Malegra 100 is a medicine that is mostly used to treat impotence or erectile dysfunction (ED) in men. It causes the penis to lose blood flow, which makes it harder to get a solid erection. Inadequate penile blood flow is the main cause of ED. The active ingredient, sildenafil, inhibits the PDE5 enzyme, which is in charge of degrading cyclic guanosine monophosphate (cGMP). The medication increases cGMP levels by inhibiting PDE5, which improves penile blood flow, which is essential for sustaining an erection. Keep in mind that the drug cannot work if there is no sexual stimulation.